CYP1A2

CYP1A2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2HI4
معین‌کننده‌ها
نام‌های دیگر	CYP1A2, CP12, P3-450, P450(PA), cytochrome P450 family 1 subfamily A member 2, Cytochrome P450 1A2, CYPIA2
شناسه‌های بیرونی	OMIM: 124060 MGI: 88589 HomoloGene: 68082 GeneCards: CYP1A2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۹ (موش)
پایان	57,590,986 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• iron ion binding; • demethylase activity; • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; • metal ion binding; • caffeine oxidase activity; • heme binding; • GO:0050602 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; • enzyme binding; • oxidoreductase activity; • aromatase activity; • electron transfer activity; • monooxygenase activity;
ترکیبات سلولی	• organelle membrane; • endoplasmic reticulum membrane; • intracellular membrane-bounded organelle; • membrane; • شبکه آندوپلاسمی;
فرایند زیستی	• response to immobilization stress; • toxin metabolic process; • steroid metabolic process; • response to estradiol; • alkaloid metabolic process; • GO:1904578 response to organic cyclic compound; • lung development; • سوخت‌وساز لیپید; • epoxygenase P450 pathway; • cellular response to cadmium ion; • post-embryonic development; • monocarboxylic acid metabolic process; • response to organic substance; • oxidative demethylation; • response to lipopolysaccharide; • متیل‌دار کردن; • steroid catabolic process; • omega-hydroxylase P450 pathway; • dibenzo-p-dioxin metabolic process; • heterocycle metabolic process; • cellular respiration; • cellular aromatic compound metabolic process; • ساماندهی بیان ژن; • hydrogen peroxide biosynthetic process; • monoterpenoid metabolic process; • xenobiotic metabolic process; • porphyrin-containing compound metabolic process; • toxin biosynthetic process; • cellular response to copper ion; • زنجیره انتقال الکترون; • long-chain fatty acid biosynthetic process;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	1544
	13077
	ENSG00000140505
	ENSMUSG00000032310
	P05177
	P00186
	NM_000761
	NM_009993
	NP_000752
	NP_034123
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

سیتوکروم پی۴۵۰ ۱ای۲ (به اختصار CYP1A2)، عضوی از سیستم اکسیداز با عملکرد مخلوط سیتوکروم P450 است که در متابولیسم بیگانه‌زیستها در بدن انسان نقش دارد.^[۴] در انسان، آنزیم CYP1A2 توسط ژن CYP1A2 کدگذاری می‌شود.^[۵]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032310 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.
↑ Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1987). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15". Journal of Experimental Pathology. 3 (1): 1–17. PMID 3681487.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000032310 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid_15128046-4] Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW (Jan 2004). "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics. 14 (1): 1–18. doi:10.1097/00008571-200401000-00001. PMID 15128046.

[pmid_3681487-5] Jaiswal AK, Nebert DW, McBride OW, Gonzalez FJ (1987). "Human P(3)450: cDNA and complete protein sequence, repetitive Alu sequences in the 3' nontranslated region, and localization of gene to chromosome 15". Journal of Experimental Pathology. 3 (1): 1–17. PMID 3681487.

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